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In a time defined by rapid technological change, economic uncertainty, and shifting assumptions about work, innovation alone is no longer enough. Leaders are being challenged to rethink not just what they build, but how and why they build it.
In this episode of the Strategy and Leadership Podcast, host Anthony Taylor sits down with JoAnn Garbin, former Microsoft innovation leader and founder of Regeneris Labs, to explore what comes after traditional innovation models. Drawing on decades of experience inside Microsoft, startups, and now a venture studio, JoAnn shares how her thinking has evolved from driving innovation within large systems to designing entirely new regenerative models for work and value creation.
JoAnn reflects on a major personal and professional inflection point that led her to step away from Big Tech and intentionally rebuild from first principles. She explains why her team spent eighteen months in what she calls an “amorphous blob” phase, experimenting, testing, and resisting the pressure to prematurely define a business model. That process ultimately led to the creation of Regeneris Labs, a venture studio designed to remove constraints and allow experienced builders to create at scale.
The conversation explores why the venture studio model offers a powerful alternative to consulting, accelerators, and traditional startups, especially in a world shaped by AI. JoAnn makes the case that AI is a disruptive force on par with steam or electrification, but argues that technology alone never creates transformation. Instead, it must be paired with new organizational and economic models, much like the factory system enabled the industrial revolution.
Anthony and JoAnn also discuss team design, trust, and why “Swiss Army knife” leaders are essential in periods of uncertainty. Rather than relying too early on deep, narrow expertise, JoAnn explains why adaptive, cross-boundary leaders are better suited to navigate constant change. The episode closes with a forward-looking exploration of capitalism, regeneration, and the opportunity to design new systems that better align technology, work, and human outcomes.
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In this episode, you will learn:
- Why innovation alone is no longer sufficient for long-term success
- How regenerative ventures differ from startups, consultancies, and accelerators
- Why AI must be paired with new organizational and economic models
- How to design teams for adaptability and trust in uncertain environments
- Why experienced builders are often constrained out of meaningful work
- What leaders can learn from historical technology-driven transformations
Connect with JoAnn Garbin
Website: https://www.joanngarbin.com/
LinkedIn: https://www.linkedin.com/in/joanngarbin/
About the Host
Anthony Taylor is the CEO and Founder of SME Strategy and a trusted expert in organizational alignment and strategy execution. With over 15 years of experience facilitating strategic planning and leadership development, he helps organizations align their people, accelerate execution, and achieve their biggest goals.
Connect with Anthony: linkedin.com/in/anthonyctaylor604
About SME Strategy
SME Strategy is a management consulting firm specializing in strategic planning and implementation. We help organizations align their teams around a shared vision so they can focus on what truly drives results.
Learn more: www.smestrategy.net
Podcast produced by: www.rednyne.com
